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Treatment of Skin Aging with Topical Estriols

Aging gracefully can mean different things to different people. For us, it means enjoying life and enjoying who you are - and for many women, this means taking care of their skin! We often feel younger than we look (which is a good thing!), but it turns out, there may be a great resource sitting in our cupboards already... This was an interesting study done to see whether topical estrogens have an effect on skin aging, particularly wrinkles that occur due to collagen loss (collagen formation is in part influenced by estrogen levels).

This study was done using two groups, estriol and estradiol. 59 women were part of the study, and the study was done over a 6 month period. 10 women had skin biopsies to assess collagen filament levels.

They found some key highlights:

  • After treatment for 6 months, elasticity and firmness of the skin had markedly improved.
  • The wrinkle depth and pore sizes had decreased by 61 to 100% in both groups.
  • Skin moisture had increased.
  • The measurement of wrinkles using skin profilometry, revealed significant, or even highly significant, decreases of wrinkle depth in the estradiol and the estriol groups, respectively.
  • Significant increases of Type III collagen labeling were combined with increased numbers of collagen fibers at the end of the treatment period. (In lay terms, base collagen levels were higher.)
  • As to hormone levels, no systemic hormonal side effects were noted.

What does this mean for you? Well, whip out that estriol cream and enjoy it as part of your skincare regimen. If you're a skincare novice, check out this blog that details all things skin!

Link: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-4362.1996.tb03701.x