This is a complex study — and it is important to note that it is looking at estradiol, NOT estriol. Estradiol is already stronger than estriol. Nevertheless, the study still found that even the stronger estradiol, when applied low dose and topically, has minimal systemic absorption — something that has long-term implications for how women's care may evolve in the future.

This study examined how low-dose vaginal estrogen treatments affect systemic estradiol levels in postmenopausal women. The researchers analyzed data from various studies, focusing on different doses and methods of measuring estradiol. They found that baseline estradiol levels in untreated postmenopausal women ranged from undetectable to 10.5 pg/mL, depending on the assay used.

During treatment, systemic estradiol levels increased in a dose-dependent manner, with higher doses leading to higher systemic absorption. The study also highlighted that the method of measuring estradiol and the placement of the estrogen product in the vagina can influence systemic absorption. These findings suggest that low-dose vaginal estrogens result in minimal systemic absorption, potentially reducing the likelihood of effects associated with higher estrogen exposure.

Additionally, during treatment with low-dose vaginal estrogens, systemic estradiol levels remained within or slightly above the normal postmenopausal range, depending on the dose and formulation. The study highlights the importance of using accurate measurement techniques and provides insights into the expected systemic absorption of estradiol with these therapies.

Learn more: https://pmc.ncbi.nlm.nih.gov/articles/PMC7050796/

This article is for educational and general wellness purposes only. It is not medical advice and is not intended to diagnose, treat, cure, or prevent any disease. If you are noticing changes in your body or have questions about your health, please consult a knowledgeable healthcare provider.