LAST DAY TO SAVE 10%* - Coupon BFCM2024
*Excludes BioNude, subscriptions, hormone tests and health coaching
- Youtube
- Home
- FAQs
- The Science of Menopause
- Systemic versus Localized with …
This is a complex study - and it is important to note that it is looking at estradiol NOT estriol. Estradiol is already stronger than estriol. Nevertheless, the study still found that even the stronger estradiol, when applied low dose and topically, has minimal systemic absorption - something that has long term implications for how women are treated in the future!
This study examined how low-dose vaginal estrogen treatments affect systemic estradiol (a form of estrogen) levels in postmenopausal women. The researchers analyzed data from various studies, focusing on different doses and methods of measuring estradiol. They found that baseline estradiol levels in untreated postmenopausal women ranged from undetectable to 10.5 pg/mL, depending on the assay used. During treatment, systemic estradiol levels increased in a dose-dependent manner, with higher doses leading to higher systemic absorption. The study also highlighted that the method of measuring estradiol and the placement of the estrogen product in the vagina can influence systemic absorption. These findings suggest that low-dose vaginal estrogens result in minimal systemic absorption, potentially reducing the risk of adverse effects associated with higher estrogen exposure.
Additionally, during treatment with low-dose vaginal estrogens, systemic estradiol levels remained within or slightly above the normal postmenopausal range, depending on the dose and formulation. The study highlights the importance of using accurate measurement techniques and provides insights into the expected systemic absorption of estradiol with these therapies.
Learn more: https://pmc.ncbi.nlm.nih.gov/articles/PMC7050796/
Lorem ipsum dolor sit amet, consectetur adipiscing elit.
Lorem ipsum dolor sit amet, consectetur adipiscing elit.
Lorem ipsum dolor sit amet, consectetur adipiscing elit.
Lorem ipsum dolor sit amet, consectetur adipiscing elit.
Disclaimer: The information provided above is intended for educational and informational purposes only. Statements made have not been evaluated by the FDA nor are they intended to treat or diagnose. Any health concerns should be discussed and evaluated by your primary health care provider.
Copyright © 2020-2025 - Parlor Games. All Rights Reserved.
Parlor Games, LLC ● kate@parlor-games.com ● 5304 River Rd N Ste B ● Keizer OR 97303
Disclaimer: The information provided above is intended for educational and informational purposes only. Statements made have not been evaluated by the FDA nor are they intended to treat or diagnose. Any health concerns should be discussed and evaluated by your primary health care provider.
Copyright © 2020-2025 - Parlor Games. All RIghts Reserved.
28 Day Challenge Subscription Details
We ship you a 28 day supply of Silky Peach Cream for only $29 (more than 25% off our normal price) when you sign up for Subscribe & Save.
Follow the directions we include in the package and apply Silky Peach cream on your tender bits for 28 days.
Decision Day:
5 days before your subscription rebills, we’ll send you an email reminder with a link. If you decide Silky Peach is nice but not your thing… you can click that link and cancel your subscription without even talking to anyone. No hassle — no questions asked.
If you are like 72% of our Silky Peach customers, you’ll love it and can't imagine life without it. In that case, do nothing, and we’ll welcome you to the Parlor Games family and ship Silky Peach Cream to your door step every month for the same discounted price of $29 — locked in for as long as you remain a subscriber.
Important note about our easy-breezy subscriptions:
We know that some companies make it hard to cancel a subscription — that’s not us. Our mission is to save the world — one vagina at a time! If you decide you don’t need Estriol as an ongoing solution for dryness, incontinence, UTIs and keeping sex fun and comfortable again, we understand. Five days before we ship your next order, you'll receive an email with a link to cancel right there in the message.
No hunting, no searching, we got you. Respect is where it’s at.
FYI – Estriol is beneficial for skin integrity and mucous membranes. It’s great for vaginal atrophy and also amazing for use on the face and neck. Applying a small amount — about 1 pump — can help build the collagen and plump up the cells to reduce wrinkles. Who knew!!
OUR HAPPINESS GUARANTEE
We want you to feel safe and confident trying any of our products. That's why we promise 100% money-back guarantee on the purchase price of the first bottle of any of our products. Balancing hormones DOES take some time, so please try it for 28 days. If after 28 days you are unhappy, or the product just hasn't worked for you, simply contact us and we'll process a refund of your full purchase price upon receipt. Sorry, shipping fees are not refundable.