0
Your Cart
Item(s)
Qty
Price

No items in your cart

 
Subtotal
$0.00
Checkout

Popular languages in United States

  • English
  • Español

Other languages

Progesterone Supplementation for Sleep
09/10/2025

We’ve long treated progesterone like the hall monitor for estrogen. Cute, but incomplete. In postmenopausal women actually struggling with insomnia, adding a progestogen to estradiol improved sleep quality in a legit randomized trial. Both versions helped; micronized progesterone was a touch easier to live with. If your nights feel like a toddler with a tambourine, progesterone deserves a seat at the sleep table.

  • 100 postmenopausal Thai women with insomnia were randomized to estradiol valerate 1 mg daily plus one of two progestogens for 3 months:
    • Dydrogesterone 10 mg daily
    • Micronized progesterone 100 mg daily
  • Sleep was measured with the Pittsburgh Sleep Quality Index (PSQI) each month.
What they found

  • Both groups slept better.
    • Average PSQI improved from 10.5 → 4.9 with dydrogesterone and 10.2 → 6.3 with micronized progesterone.
    • The difference between the two groups was not statistically significant (p=0.08), meaning the trial couldn’t confidently say one was better for sleep than the other.
  • Side effects: The micronized progesterone group reported fewer overall side effects than the dydrogesterone group.

What it means (takeaways)

  • If you’re using estrogen therapy and need a progestogen, either dydrogesterone (10 mg) or micronized progesterone (100 mg), taken daily with estradiol, was associated with meaningful sleep improvement over 3 months.
  • This study wasn’t large enough to prove a clear winner for sleep; it only hints that both help, with micronized progesterone possibly better tolerated.
  • Important nuance: This trial tested progestogens added to estradiol, not progestogen alone.

Adding either dydrogesterone 10 mg or micronized progesterone 100 mg to estradiol 1 mg improved sleep in postmenopausal women with insomnia over 3 months; no clear difference in sleep outcomes, but micronized progesterone had fewer side effects.