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NAD+ and Your Skin
09/03/2025
We all know skin changes with age — it gets thinner, drier, and loses that youthful bounce. One of the lesser-known drivers behind this transformation? A molecule called NAD⁺ (nicotinamide adenine dinucleotide). Think of NAD⁺ as the fuel that powers your skin cells’ little engines (mitochondria). It helps convert nutrients into energy, repairs DNA, and supports protective enzymes that keep skin resilient. The catch: as we age, our NAD⁺ levels decline, which means our skin cells can’t work as efficiently as they once did. The result? Slower repair, less collagen, more visible fine lines, and thinner, more fragile skin.
Researchers have been investigating whether NAD⁺ precursors — compounds that the body can turn into NAD⁺ — could help restore this lost vitality. Two of the most promising are nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), both forms of vitamin B3. When tested in human skin cells, these compounds were able to increase NAD⁺/NADH levels and stimulate procollagen-1 production, which is critical for maintaining firm, smooth skin. Even more exciting, combining niacinamide with certain peptides and plant extracts shifted skin cell activity toward a “younger” profile: genes responsible for collagen and elastin were switched on, while collagen-breaking enzymes were dialed down.
What does this mean for you? While more research is needed, especially in large, long-term human studies, the science suggests that boosting NAD⁺ may be a smart way to help skin recharge its energy, rebuild its structure, and age more gracefully. Instead of only focusing on surface fixes, future skincare might tap into cellular bioenergetics — essentially giving your skin the fuel it needs to act young again.
Here is the study: https://academic.oup.com/bjd/article-abstract/169/...
Osborne, R., Carver, R. S., Mullins, L. A., & Finlay, D. R. (2013). Practical application of cellular bioenergetics to the care of aged skin. British Journal of Dermatology, 169(s2), 32–38.
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Disclaimer: The information provided above is intended for educational and informational purposes only. Statements made have not been evaluated by the FDA nor are they intended to treat or diagnose. Any health concerns should be discussed and evaluated by your primary health care provider.
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Disclaimer: The information provided above is intended for educational and informational purposes only. Statements made have not been evaluated by the FDA nor are they intended to treat or diagnose. Any health concerns should be discussed and evaluated by your primary health care provider.
Copyright © 2020-2025 - Parlor Games. All RIghts Reserved.
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We know that some companies make it hard to cancel a subscription — that’s not us. Our mission is to save the world — one vagina at a time! If you decide you don’t need Estriol as an ongoing solution for dryness, incontinence, UTIs and keeping sex fun and comfortable again, we understand. Five days before we ship your next order, you'll receive an email with a link to cancel right there in the message.
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