How the Research Was Conducted

The researchers examined the link between chronic stress and accelerated aging by reviewing evidence from multiple fields, including human population studies, animal research, and cellular experiments. They looked at studies measuring stress levels and biological aging markers (such as telomere length, inflammation, mitochondrial function, and DNA damage), analyzed laboratory work where cells were exposed to stress hormones, and evaluated animal models subjected to long-term stress. By integrating findings from genetics, epigenetics, immunology, mitochondrial biology, and neuroendocrinology, they built a unified picture of how chronic stress affects the body’s major aging pathways.

Key Findings

1. Chronic stress shortens telomeres

Across many human studies, people experiencing long-term stress show significantly shorter telomeres (something we also talk about in regards to NAD in MoreWOW!), meaning their cells reach “old age” sooner. Telomere shortening was observed in immune cells, cardiovascular tissues, and brain-related cells.

2. Stress creates persistent inflammation (“inflammaging”)

The review found that chronic exposure to stress hormones pushes the immune system into a constant, low-grade inflammatory state. Over time, this inflammation contributes to tissue damage, reduced repair, and faster biological aging.

3. Stress causes oxidative stress and DNA damage

Long-term stress increases the production of reactive oxygen species (ROS). These molecules damage DNA, proteins, lipids, and especially mitochondria. Damaged mitochondria produce even more ROS, creating a vicious cycle that speeds aging.

4. Stress disrupts mitochondrial function

Mitochondria become less efficient at producing energy (ATP) when exposed to chronic stress signals. Damaged mitochondria accumulate because the normal cleanup process (mitophagy) becomes impaired. Low cellular energy = slower repair and regeneration.

5. Stress increases cellular senescence

Stressed cells are more likely to enter a “senescent” state - they stop dividing, secrete inflammatory chemicals, and interfere with normal tissue renewal. Accumulation of these senescent cells is a major driver of visible and internal aging.

6. Stress affects epigenetic aging

The review included studies showing stress-related changes in DNA methylation patterns, which are the markers used to calculate “epigenetic clocks.” High chronic stress consistently correlated with older biological age compared to chronological age.

7. Stress-related aging increases risk of chronic disease

The biological changes above increase the risk for:

• cardiovascular disease
• diabetes
• cognitive decline
• weakened immunity
• metabolic dysfunction

Takeaways

Chronic stress does not just influence mood or daily functioning - it pushes multiple aging pathways at once. It accelerates aging at the genetic, mitochondrial, inflammatory, and epigenetic levels, making stressed individuals biologically older than their non-stressed peers.

The study emphasizes that managing chronic stress is not simply about mental health but is directly tied to slowing biological aging, protecting cellular function, and reducing long-term disease risk.

View the study here: https://www.mdpi.com/2227-9059/8/7/198

You can also watch Dr. Robyn discuss this on 'Ask Dr. Robyn' - Wednesdays at 4pm PST inside the Sexy Sassy Sisterhood!