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Estriol for Stress Incontienence
10/12/2023

Stress Incontinence is defined as the involuntary, sudden loss of urine secondary to increased intraabdominal pressure that is bothersome or affecting the patient's quality of life. Physical activities precipitating stress incontinence include laughing, sneezing, straining, coughing, or exercising.

Stress incontinence is more common post menopause... why, you ask? Well, it is thought to be a combination of factors including loss of muscle tone and the early symptoms of vaginal atrophy from the lowered levels of estrogen. In order to counteract this, this study looked at a 12 week program of estriol to see whether this was effective at treating stress incontinence.

There were 46 women with a median age of 62; all women were instructed to apply 0.5 mg of estriol cream digitally to the lower third of the vagina and around the opening of the urethra, every night for the first 3 weeks and then twice a week for the remainder 9 weeks, therefore 12 weeks in total.

The study found that, "vaginal estriol cream significantly reduced symptoms of SUI in this sample of postmenopausal women. No major adverse effects were found, therefore estriol cream can be considered as a possible first line treatment for SUI in such women."

Check out the study here: https://onlinelibrary.wiley.com/doi/full/10.1002/nau.25165