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DHEA for Muscle Mass in Aging Adults
07/09/2025

Summary for Real Life:

This study looked at older adults (men and women aged 65–75) and asked:
What happens when they take DHEA (a hormone that declines with age) and do resistance training?

Spoiler: They got stronger, faster, and gained more muscle than with weight training alone.

Key Takeaways:

  • DHEA on its own didn’t build much muscle or strength.
  • Weight training on its own helped improve strength and increase lean muscle (as expected).
  • But the combo of DHEA + strength training did significantly better in both:
    • Muscle mass gains (especially in the legs)
    • Muscle strength
    • Fat mass loss

So in simple terms:
DHEA acted like a power-up button—it made their training more effective and helped reverse some age-related muscle loss.

What This Means for Women 40+:

Even though this study was in older adults, it has big implications for midlife women who are:

  • Losing muscle and strength due to declining estrogen and DHEA
  • Starting or already doing weight training
  • Experiencing fatigue or poor recovery

Using DHEA (carefully, and ideally under guidance) might enhance your gains, help with energy and mood, and make your workouts work harder for you.


LINK: https://journals.physiology.org/doi/full/10.1152/a...