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Picture of Chart, Plot, Person, Advertisement, Poster, Head with text DHEA and Age Related Musculosk...
DHEA Research and Midlife Musculoskeletal Wellness
08/20/2025

DHEA is a hormone that naturally declines with age — and researchers have been exploring what that means for how our bodies maintain bone density, muscle mass, and joint comfort over time. Here's a plain-English look at what the science has found so far.

This article is for educational and general wellness purposes only. It is not medical advice and is not intended to diagnose, treat, cure, or prevent any disease. If you are noticing changes in your body or have questions about your health, please consult a knowledgeable healthcare provider.

The Science (Simplified)

  • What is DHEA?
    DHEA is made mostly in the adrenal glands. It's a "precursor" hormone — meaning your body can convert it into sex hormones like estrogen and testosterone.
  • Why does it matter?
    DHEA peaks in early adulthood and declines steadily after age 30–40. Research suggests that by the time people reach their 70s or 80s, levels may be only about 10–20% of what they were in youth. This natural decline is associated with changes in how the body maintains bone density, muscle mass, and joint comfort as we age.
  • What researchers have explored:
    1. Bone Health:
      • DHEA plays a role in the body's natural bone maintenance processes.
      • It is involved in the balance between osteoblasts (cells that build bone) and osteoclasts (cells that break bone down) as part of healthy aging.
      • Researchers have been studying how age-related DHEA changes may relate to bone density over time.
    2. Muscle Health:
      • DHEA converts into hormones that play a role in how the body maintains lean tissue and energy as we age.
      • It is also associated with IGF-1 (Insulin-like Growth Factor 1), a hormone involved in how the body supports muscle tissue.
      • Scientists continue to explore how declining DHEA levels relate to changes in muscle strength and mass in older adults.
    3. Joint Comfort:
      • DHEA may support the body's natural processes for maintaining joint comfort and flexibility as part of overall healthy aging.
      • Research is ongoing into how DHEA relates to the body's natural cartilage maintenance over time.

What the Research Has Found

  • Some research has explored how DHEA may relate to overall physical wellness in older adults — though more evidence is needed on optimal approaches, duration, and long-term outcomes.
  • The research population in many studies has included people in midlife and beyond, where hormone changes are more pronounced.
  • Results vary across studies, and this remains an active area of scientific inquiry.

The Takeaway

  • DHEA is a hormone that declines naturally with age, and researchers have been exploring what that means for how the body maintains bone density, muscle mass, and joint comfort.
  • As DHEA naturally declines with age, emerging research suggests it may play a supportive role in overall physical wellness. More studies are ongoing.
  • If you have questions about your hormone levels or what changes you're noticing in your body, a conversation with your healthcare provider is a great place to start.

This article is for educational and general wellness purposes only. It is not medical advice and is not intended to diagnose, treat, cure, or prevent any disease. If you are noticing changes in your body or have questions about your health, please consult a knowledgeable healthcare provider.

Parlor Games products are not intended to treat, cure, prevent, or mitigate disease or other medical conditions. Our products are not the subject of the studies discussed herein, and we do not claim that our products will have the same effects as those discussed in these articles. This information is being provided for educational purposes only, and is not intended to replace the advice of a medical professional.